How to Cite
Linarez, N. E., Lavadie Rivas, F., Reyes, I., Durón, R. M., & Rodríguez, G. (2024). Methotrexate in compassionate use improved acute pneumonia and myocarditis in a patient with COVID-19. Innovare Revista De Ciencia Y tecnología, 10(3), 138. Retrieved from https://revistas.unitec.edu/innovare/article/view/172
Abstract
Chest CT scan of a 26-year-old Honduran male with COVID-19 and moderate pneumonia (A, arrows). Due to tocilizumab shortage, compassionate use of methotrexate (MTX) was done in a single 25mg IV dose by day 11 of disease, under monitoring by an ad-hoc ethics commission. Two weeks after initial clinical improvement, he developed acute myocarditis with atrioventricular block (B). Remission occurred after a second dose of the drug (C, D). MTX is well known by its use in several oncological and autoimmune conditions, and by its potential in reducing phosphorylation of JAK1/STAT3 and IL6 expression. Several reports suggest that MTX could be repurposed as therapy for the cytokine storm due to SARS-CoV-2
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